Hyperbaric oxygen therapy as a complementary treatment in neuroblastoma — a narrative review

Neuroblastoma is the most frequently diagnosed cancer during first year of life. This neoplasm originates from neural crest cells derived sympathetic nervous system, adrenal medulla, or paraspinal ganglia. The clinical presentation can vary an asymptomatic mass to symptoms resulting local invasion and/or spread distant disease spread. natural history neuroblastoma highly variable, ranging relatively indolent biological behavior a high-risk phenotype with dismal prognosis. Age, stage, and features are important prognostic risk stratification treatment assignment factors. multimodal therapy approach includes myeloablative chemotherapy, radiotherapy, immunotherapy, aggressive surgical resection. Hyperbaric oxygen (HBOT) has been proposed as complementary measure overcome tumor hypoxia, which considered one hallmarks this resistance. article aims review relevant literature on pathophysiology, presentation, different genetic profiles, discuss its management, focusing HBOT.